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This extensively updated edition provides a comprehensive review of intensive care for neurologically injured patients from the emergency room and ICU through the operating room and post-surgical period in two comprehensive volumes. The Editors of this second volume present a comprehensive textbook that incorporates best practice/evidence-based medicine and performance improvement, while it champions the three characteristics needed in our neuro–ICUs: patient and family centered high-quality care, education, and discovery. This volume concentrates on perioperative management, monitoring and pharmacotherapy, examining the neurological problems most frequently seen in intensive care, and describes the various types of neurosurgery and critical features of the management of patients. General issues are discussed across the textbook, such as cardiac care, fluids and electrolytes, nutrition, and monitoring as well as more specific conditions and complications including elevated intracranial pressure, seizures, and altered mental states.
Listening to an injured brain is not easy. It takes knowledge, dedication, and understanding of the critically ill patient and their family. Textbook of Neurointensive Care Volume 2: Perioperative Management, Monitoring, Pharmacotherapy provides the reader with a detailed resource for studying this most complex area of medicine. It is thus essential reading for all trainees and professionals in critical care, neurosurgery, anesthesia and neurology.
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Table of contents (28 chapters)
Front Matter
Pages i-xii
Priorities in Perioperative Management
Front Matter
Pages 1-1
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Intraoperative Neuroanesthesia
Elizabeth Mahanna Gabrielli, Steven A. Robicsek, Dietrich Gravenstein, Nikolaus Gravenstein, David L. McDonagh
Pages 3-18
Postoperative Care for the Neurosurgical Patient: Cranial Procedures
Lucas R. Philipp, Caio M. Matias, Peter Le Roux, Jack Jallo
Pages 19-36
Complex Spine Surgery
Ken Porche, Daniel J. Hoh, Basma Mohamed, Adam Polifka, Matthew Decker
Pages 37-59
Monitoring and Procedures
Front Matter
Pages 61-61
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Airway Management in the Neurointensive Care Unit
Felipe Urdaneta, Ya-Chu May Tsai, Matteo Parotto
Pages 63-86
Critical Care Procedures
Brad R. Withers, Kevin W. Hatton
Pages 87-114
Echocardiography and Ultrasound Applications
Nawar Al-Rawas, Ron Leong, Eric Feduska, Ettore Crimi
Pages 115-128
Invasive Neurological and Multimodality Monitoring in the Neuro-ICU
Omer Doron, Guy Rosenthal, Peter Le Roux
Pages 129-152
Noninvasive Neuromonitoring
Kathryn R. Rosenblatt, Vishank A. Shah, Mariyam Humayun, Veronika Solnicky, Ozan Akça
Pages 153-179
Integrated Approaches to Multimodality Monitoring of Cerebral Physiology
Ramani Balu
Pages 181-191
Neurological Applications of Hemodynamics and Pulmonary Monitoring
Krupa Savalia, Atul Kalanuria, W. Andrew Kofke
Pages 193-209
Severe Neurological Complications of Critical Illness
Front Matter
Pages 211-211
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Systemic Illness and Multisystem Organ Failure
Aaron N. LacKamp, Robert D. Stevens, Peggy A. White
Pages 213-230
Environmental Injury: Toxins, Overdose, Drowning, Thermal Burns
Jared Ham
Pages 231-241
Consultative Neurocritical Care
Chitra Venkatasubramanian, Kyle Lyman, Varun Shah
Pages 243-268
Pharmacotherapy
Front Matter
Pages 269-269
Sedation, Analgesia and Muscle Relaxation in NICU
Angelo Guglielmi, Marta Baggiani, Chiara Almondo, Giuseppe Citerio
Pages 271-286
Anticoagulants and Reversal Agents
Sulaiman Almohaish, Gretchen M. Brophy
Pages 287-301
Pharmacotherapy
Antiplatelet Agents and Platelet Function Assays
Aaron M. Cook, Blake Robbins, Devin Holden
Pages 303-311
Thrombolytics and Antifibrinolytics
Amanda Lamer-Rosen, Michelle Payne
Pages 313-323
Osmotherapy
Daitiara Perez, Shantal Alcoba, Marlene Onaindia
Pages 325-333
Steroids and Immunomodulating Agents
Shantal Alcoba, Daitiara Perez
Pages 335-345
Anticonvulsants
Meghan M. Vallejo, Karen Berger
Pages 347-365
Neurostimulants
Jeffrey J. Mucksavage, Micheal J. Strein, Eljim P. Tesoro
Pages 367-377
Quality Improvement, Patient Safety and Systems Issues
Front Matter
Pages 379-379
Quality Metrics and Performance Measures in Neurocritical Care
Abhijit V. Lele, Asma Moheet
Pages 381-388
Early Mobilization and Acute Rehabilitation in the NeuroICU
R. Formisano, M. Aloisi, E. Azicnuda, D. Silvestro, M. P. Ciurli, U. Bivona
Pages 389-403
Nutrition in the Neurocritically Ill Patient
Brandon L. Overholt, Neeraj Badjatia
Pages 405-420
Global Neurocritical Care
Ernest J. Barthélemy, Emnet Tesfaye, Simon G. Ammanuel, Roxanna M. Garcia, Joshua Medow, Gail Rosseau
Pages 421-435
Ethical and Legal Considerations of Neurocritical Care
C. Naglee, J. Komisarow, S. J. Reif
Pages 437-444
Disaster Response
Donald R. Sessions, A. Joseph Layon
Pages 445-458
Research Challenges in the ICU
Sara Venturini, Alasdair Jubb, Adel Helmy
Pages 459-467
Back Matter
Pages 469-481
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About the Author
Dr A. Joseph Layon is Professor of Anesthesiology at the University of Central Florida College of Medicine and Medical Director of the Medical-Surgical ICU at HCA-Florida-Lake City Hospital. He has worked throughout the US and in countries as disparate as Nicaragua and Nigeria, the latter with Medecins sans Frontieres. His most recent published work has been on the sociology and philosophy of medicine, and he is involved with groups such as Physicians for a National Health System and Jewish Voice for Peace.
Dr Andrea Gabrielli is a Professor of Anesthesiology, Perioperative Medicine, and Pain Management at the University of Miami Miller School of Surgery. He is currently the Chief of Anesthesiology Critical Care Medicine. He received his medical degree from the University of Rome and trained at the Cleveland Clinic and the University of Florida. He is board-certified in General Surgery (EC) and Anesthesiology with board-specialty qualifications in Critical Care Medicine and Neurointensive Care. His academic interests have included research in cardiopulmonary resuscitation, neurotrauma, respiratory care, and health care innovation.
Dr Peter Le Roux received his medical degree and doctorate in neuroscience from the University of Cape Town in South Africa and trained in Neurosurgery at the University of Washington in Seattle, WA, USA. This included training at Atkinson Morley Hospital in London, England and research at the Ecole Normale Superieure in Paris, France. He currently is Professor of Neurosurgery at the University of Rochester.
Dr Le Roux has a longstanding record in translational research in brain resuscitation and recovery and is an internationally known expert in subarachnoid hemorrhage and traumatic brain injury management and in neurocritical care. His basic science focused on factors that mediate neuronal dendrite growth. He has contributed to the traumatic brain injury guidelines for Emergency Neurological Life Supportand the International Olympic Committee. Dr Le Roux has given more than 330 invited lectures in 15 countries.
He has been recognized with the Young Neurosurgeon Award from the World Federation of Neurosurgical Societies, the Charles A. Elsberg Fellow of the New York Academy of Medicine and is listed in US News and World Report's 'Top Doctors'; Best Doctors in America, Who’s Who in the World, America’s Top Surgeons and Philadelphia’s Top Doctors. In 2015 he received the Presidential Service Award from the Neurocritical Care Society.
Dr Kristine O’Phelan received her medical degree from Boston University School of Medicine. She completed a residency in neurology at the University of Miami, Jackson Memorial Hospital, and fellowship training in Neurotrauma and Neurocritical Care at the University of California, Los Angeles Center for Health Sciences, Division of Neurosurgery. She is certified by The American Board of Psychiatry and Neurology and the United Council for Neurologic Subspecialties. Her major subspecialty interest is in critical care of neurotrauma, subarachnoid hemorrhage and other neurosurgical illnesses. Dr O’Phelan is a Professor of Clinical Neurology and has been with the Department of Neurology in the University of Miami, Miller School of Medicine and Director of Neurocritical Care since 2008.
Dr Elizabeth Mahanna Gabrielli is an Associate Professor of Anesthesiology, Perioperative Medicine, and Pain Management at the University of Miami Miller School of Medicine and Division Chief of Geriatric Anesthesiology. She completed her medical doctorate at the University of Texas at Southwestern in 2007 and her residency in Anesthesiology at Rush University in 2011. She completed fellowships in Critical Care Medicine and Neuroanesthesiology at the University of Florida and an NIH T32 research fellowship at the University of Pennsylvania focusing on Perioperative Brain Health in the geriatric population. She is board certified in Anesthesiology, Critical Care Medicine, and Neurocritical care. She is passionate about education and spends her clinical time attending and teaching Neurocritical Care, Neuroanesthesiology and Geriatric Anesthesiology. She is on the American Board of Anesthesiology’s Critical Care Committee since 2021 and previously was a question author since 2012. She is the Neuroanesthesia section editor for Open Anesthesiology, the chair of the Education subcommittee of the Society of Critical Care Medicine’s Anesthesiology Section, and the chair for the American Society of Anesthesiology Perioperative Brain Health Initiative.
Joshua M. Levine, MD, FANA, FNCS is a Professor and Vice Chair of Clinical Operations for the Department of Neurology at the University of Pennsylvania. He is founder and Chief of the Division of Neurocritical Care at Penn. Dr Levine earned his MD from Harvard Medical School. He completed residency training in Neurology at the University of Pennsylvania and fellowship training in neurocritical care and vascular neurology at Massachusetts General Hospital. Dr Levine’s research has largely focused on using multimodality neuromonitoring to better understand the pathophysiology of severe brain injury and on discerning the optimal use of multimodality neuromonitoring in clinical practice.
Monisha A. Kumar, MD, FNCS is a Professor of Neurology, Vice Chair for Quality and Safety, and Medical Director of the Neuro ICU at the Hospital of University of Pennsylvania. She is a neurointensivist and clinical researcher whose area of expertise is in coagulation derangements associated with severe brain injury. She is the immediate past chair of the Penn Forum for Women Faculty through the Office of the Provost and the current chair of the Anna T. Meadows Society, a faculty development group for clinical researchers, through the Office of Academic Affairs. She chaired the Neurocritical Care Society (NCS) Guidelines Committee and has authored joint guidelines between NCS and the Society for Critical Care Medicine. She completed her tenure on the NCS Board of Directors and the NCS Executive Committee and served as the Board liaison to the Inclusion in Neurocritical Care Committee, the diversity, equity, inclusion and belonging committee of the NCS. Additionally, she serves on the scientific programming committee for the American Stroke Association.
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